Basically this article discuss about hydrocortisone use in sepsis patient. Their hypothesis sepsis cause hyper-inflammatory responses and cause shock. So by giving hydrocortisone, by theory should reduce the morbidity and mortality because steroid reduce inflammation. But HYPRESS study not enough sample to came out with significant suggestion or recommendation. So they think, sepsis is not as simple as hyper-inflammation. For now, the use of hydrocortisone for sepsis patient still not a practical till further study.