PulmCrit- Metabolic sepsis resuscitation: the evidence behind Vitamin C

https://emcrit.org/pulmcrit/metabolic-sepsis-resuscitation/

mitochondria

Key knowledge here:
Vitamin C and Thiamine Vit B1 is not producable by human body but consumable.

Storage is limited and can be depleted in stress condition

In sepsis, vitamin C can be as low as undetectable in most of patient. A third of sepsis patient have low thiamine.

Vitamin C – required to produce cathecholamine
Thiamine – lack of thiamine can lead to wet beriberi. Mimic distrubutive shock

If we combine the lack of these two vitamins. Lead to profound shock

But we know, nobody measure it and it pass unnoticed.

Vitamin C and thiamine is quite safe. A lot of study and proved.

For time being no large and multicenter RCT (level I evident)

But nearly all of our current therapies for sepsis lack level-I evidence.

Multiple research have shown, reduce in vasopressor use, ventilatory support and mortality.

So far, we have HYPRESS, talk about role of hydrocortisone.

So Dr Marik combine these 3 things up = Dr Marik’s cocktail.

So far have a good outcome.

In conclusion : it’s safe, no harm to give. But not in guideline yet. Up to HOD.

Here the cocktails guys. IV not stir up. Hahaha.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Create a free website or blog at WordPress.com.

Up ↑

%d bloggers like this: